Drug interactions
Pentobarbital + Ramelteon
Severity: Moderate
Pentobarbital and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic enzymes including CYP1A2 and may reduce ramelteon exposure and effect. Both agents are also sedating, so additive CNS depression may occur.
What this interaction means in plain words
Pentobarbital and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP1A2 induction lowers ramelteon levels, together with additive CNS depression.
What to do
Monitor ramelteon efficacy and daytime sedation; avoid combined hypnotic use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Pentobarbital with Ramelteon?
MediHelp rates the interaction as moderate. Pentobarbital and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces hepatic enzymes including CYP1A2 and may reduce ramelteon exposure and effect. Both agents are also sedating, so additive CNS depression may occur.
How serious is the interaction between Pentobarbital and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ramelteon efficacy and daytime sedation; avoid combined hypnotic use where possible.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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