Drug interactions
Pentobarbital + Repaglinide
Severity: Moderate
Pentobarbital and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower repaglinide concentrations, reducing its glucose-lowering effect.
What this interaction means in plain words
Pentobarbital and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pentobarbital induces CYP3A4 (and possibly CYP2C8), increasing repaglinide clearance.
What to do
Monitor blood glucose when pentobarbital is started or stopped, and adjust the repaglinide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Pentobarbital with Repaglinide?
MediHelp rates the interaction as moderate. Pentobarbital and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may lower repaglinide concentrations, reducing its glucose-lowering effect.
How serious is the interaction between Pentobarbital and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pentobarbital is started or stopped, and adjust the repaglinide dose accordingly.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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