Drug interactions
Pentobarbital + Tolbutamide
Severity: Minor
Pentobarbital and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital can induce hepatic enzymes and may speed the clearance of tolbutamide. This could reduce glycemic control, although the effect of short-term use is usually modest.
What this interaction means in plain words
Pentobarbital and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP2C9 increases tolbutamide metabolism.
What to do
Monitor glucose when pentobarbital is used regularly and increase the tolbutamide dose if control worsens. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Pentobarbital with Tolbutamide?
MediHelp rates the interaction as minor. Pentobarbital and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital can induce hepatic enzymes and may speed the clearance of tolbutamide. This could reduce glycemic control, although the effect of short-term use is usually modest.
How serious is the interaction between Pentobarbital and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when pentobarbital is used regularly and increase the tolbutamide dose if control worsens. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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