Drug interactions
Pentobarbital + Vardenafil
Severity: Moderate
Pentobarbital and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may lower vardenafil concentrations, reducing its effect. Barbiturate induction can develop over days and persist after discontinuation.
What this interaction means in plain words
Pentobarbital and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic and intestinal CYP3A4 increases vardenafil clearance.
What to do
Monitor for reduced response to vardenafil. Consider an alternative treatment if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Pentobarbital with Vardenafil?
MediHelp rates the interaction as moderate. Pentobarbital and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may lower vardenafil concentrations, reducing its effect. Barbiturate induction can develop over days and persist after discontinuation.
How serious is the interaction between Pentobarbital and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to vardenafil. Consider an alternative treatment if efficacy is lost.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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