Drug interactions
Pentobarbital + Ziprasidone
Severity: Moderate
Pentobarbital and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is a barbiturate that causes dose-related CNS and respiratory depression, which ziprasidone can add to. Pentobarbital is also a CYP3A4 inducer and may lower ziprasidone exposure with prolonged use.
What this interaction means in plain words
Pentobarbital and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus CYP3A4 induction by pentobarbital.
What to do
Monitor sedation and respiratory status, and reassess antipsychotic response during prolonged barbiturate use. Reduce doses of the sedatives if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Pentobarbital with Ziprasidone?
MediHelp rates the interaction as moderate. Pentobarbital and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital is a barbiturate that causes dose-related CNS and respiratory depression, which ziprasidone can add to. Pentobarbital is also a CYP3A4 inducer and may lower ziprasidone exposure with prolonged use.
How serious is the interaction between Pentobarbital and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and reassess antipsychotic response during prolonged barbiturate use. Reduce doses of the sedatives if drowsiness is excessive.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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