Drug interactions
Pentosan polysulfate + Warfarin
Severity: Moderate
Pentosan polysulfate and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentosan polysulfate is a weak heparin-like anticoagulant and may add to the bleeding risk of warfarin. It can also have mild effects on coagulation tests. Combined use may cause bruising or more serious bleeding.
What this interaction means in plain words
Pentosan polysulfate and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticoagulant effect, as pentosan polysulfate has weak heparin-like activity and affects coagulation and platelet function.
What to do
Monitor INR and watch for signs of bleeding when starting or stopping pentosan polysulfate. Adjust the warfarin dose as needed, and reassess the need for both agents in patients with bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Pentosan polysulfate with Warfarin?
MediHelp rates the interaction as moderate. Pentosan polysulfate and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentosan polysulfate is a weak heparin-like anticoagulant and may add to the bleeding risk of warfarin. It can also have mild effects on coagulation tests. Combined use may cause bruising or more serious bleeding.
How serious is the interaction between Pentosan polysulfate and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and watch for signs of bleeding when starting or stopping pentosan polysulfate. Adjust the warfarin dose as needed, and reassess the need for both agents in patients with bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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