Drug interactions
Peramivir + Vancomycin
Severity: Minor
Peramivir and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is eliminated mainly by the kidneys, and vancomycin can impair renal function. Reduced kidney function could raise peramivir exposure, although peramivir has a fairly wide safety margin.
What this interaction means in plain words
Peramivir and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Vancomycin-related nephrotoxicity may reduce renal clearance of peramivir.
What to do
Monitor renal function during combined use. Adjust the peramivir dose if creatinine clearance falls below the labeled thresholds.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Peramivir with Vancomycin?
MediHelp rates the interaction as minor. Peramivir and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peramivir is eliminated mainly by the kidneys, and vancomycin can impair renal function. Reduced kidney function could raise peramivir exposure, although peramivir has a fairly wide safety margin.
How serious is the interaction between Peramivir and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during combined use. Adjust the peramivir dose if creatinine clearance falls below the labeled thresholds.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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