Drug interactions
Perindopril + Phentolamine
Severity: Moderate
Perindopril and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is an alpha-blocker that causes vasodilation, and with an ACE inhibitor the fall in blood pressure can be exaggerated. Symptomatic hypotension, dizziness or syncope may occur.
What this interaction means in plain words
Perindopril and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perindopril belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-adrenergic blockade and renin-angiotensin inhibition.
What to do
Monitor blood pressure closely during phentolamine use and have supine positioning and fluids available for hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Perindopril with Phentolamine?
MediHelp rates the interaction as moderate. Perindopril and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is an alpha-blocker that causes vasodilation, and with an ACE inhibitor the fall in blood pressure can be exaggerated. Symptomatic hypotension, dizziness or syncope may occur.
How serious is the interaction between Perindopril and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during phentolamine use and have supine positioning and fluids available for hypotension.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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