Drug interactions
Perindopril + Probenecid
Severity: Minor
Perindopril and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may modestly reduce renal clearance of perindoprilat, which could slightly increase blood pressure lowering.
What this interaction means in plain words
Perindopril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perindopril belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular secretion of perindoprilat via organic anion transporters.
What to do
Monitor blood pressure after starting probenecid and adjust the perindopril dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Probenecid?
MediHelp rates the interaction as minor. Perindopril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid may modestly reduce renal clearance of perindoprilat, which could slightly increase blood pressure lowering.
How serious is the interaction between Perindopril and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting probenecid and adjust the perindopril dose if hypotension develops.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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