Drug interactions
Pexidartinib + Phenytoin
Severity: Major
Pexidartinib and Phenytoin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin lowers pexidartinib exposure, which may reduce efficacy. Both agents can also cause liver injury, and pexidartinib carries a boxed warning for serious hepatotoxicity.
What this interaction means in plain words
Pexidartinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing pexidartinib clearance, and both drugs have additive hepatotoxic potential.
What to do
Avoid combination and use a non-inducing, non-hepatotoxic antiseizure drug. If unavoidable, monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Phenytoin?
MediHelp rates the interaction as major. Pexidartinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin lowers pexidartinib exposure, which may reduce efficacy. Both agents can also cause liver injury, and pexidartinib carries a boxed warning for serious hepatotoxicity.
How serious is the interaction between Pexidartinib and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and use a non-inducing, non-hepatotoxic antiseizure drug. If unavoidable, monitor liver tests closely.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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