Drug interactions
Pexidartinib + Pimozide
Severity: Moderate
Pexidartinib and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib induces CYP3A4 and can lower pimozide concentrations, risking loss of efficacy. Dose changes are difficult because pimozide has a narrow therapeutic window.
What this interaction means in plain words
Pexidartinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pexidartinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
CYP3A4 induction by pexidartinib accelerates pimozide metabolism.
What to do
Avoid if possible; otherwise monitor clinical response and ECG and adjust the pimozide dose as needed. Reassess the dose when pexidartinib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Pimozide?
MediHelp rates the interaction as moderate. Pexidartinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib induces CYP3A4 and can lower pimozide concentrations, risking loss of efficacy. Dose changes are difficult because pimozide has a narrow therapeutic window.
How serious is the interaction between Pexidartinib and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor clinical response and ECG and adjust the pimozide dose as needed. Reassess the dose when pexidartinib is discontinued.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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