Drug interactions
Pexidartinib + Rabeprazole
Severity: Major
Pexidartinib and Rabeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib absorption is reduced when gastric pH is raised, and proton pump inhibitors lower its exposure. This may reduce efficacy in tenosynovial giant cell tumor.
What this interaction means in plain words
Pexidartinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces the solubility and absorption of pexidartinib.
What to do
Avoid proton pump inhibitors. If acid suppression is needed, take pexidartinib 2 hours before or after an antacid, or at least 2 hours before or 10 hours after an H2 antagonist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Rabeprazole?
MediHelp rates the interaction as major. Pexidartinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib absorption is reduced when gastric pH is raised, and proton pump inhibitors lower its exposure. This may reduce efficacy in tenosynovial giant cell tumor.
How serious is the interaction between Pexidartinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid proton pump inhibitors. If acid suppression is needed, take pexidartinib 2 hours before or after an antacid, or at least 2 hours before or 10 hours after an H2 antagonist.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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