Drug interactions
Pexidartinib + Thioguanine
Severity: Major
Pexidartinib and Thioguanine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and sometimes fatal hepatotoxicity, and thioguanine can also cause liver injury including veno-occlusive disease. Using them together may increase the risk of liver damage.
What this interaction means in plain words
Pexidartinib and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Thioguanine belongs to Oncology.
Why it happens
Additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Avoid the combination where possible. If both are needed, check liver enzymes and bilirubin before and regularly during treatment and stop pexidartinib for significant elevations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioguanine
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Thioguanine?
MediHelp rates the interaction as major. Pexidartinib and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and sometimes fatal hepatotoxicity, and thioguanine can also cause liver injury including veno-occlusive disease. Using them together may increase the risk of liver damage.
How serious is the interaction between Pexidartinib and Thioguanine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, check liver enzymes and bilirubin before and regularly during treatment and stop pexidartinib for significant elevations.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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