Drug interactions
Phendimetrazine + Procarbazine
Severity: Contraindicated
Phendimetrazine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic related to amphetamine, and procarbazine inhibits MAO. The combination may precipitate a hypertensive crisis.
What this interaction means in plain words
Phendimetrazine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition potentiates catecholamine release by indirect sympathomimetics.
What to do
Avoid the combination. Allow at least 14 days after stopping procarbazine before starting phendimetrazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Procarbazine?
MediHelp rates the interaction as contraindicated. Phendimetrazine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phendimetrazine is a sympathomimetic anorectic related to amphetamine, and procarbazine inhibits MAO. The combination may precipitate a hypertensive crisis.
How serious is the interaction between Phendimetrazine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Allow at least 14 days after stopping procarbazine before starting phendimetrazine.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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