Drug interactions
Phendimetrazine + Ziprasidone
Severity: Moderate
Phendimetrazine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that can raise heart rate and blood pressure, whereas ziprasidone prolongs the QT interval. Stimulant-induced tachycardia may add to arrhythmic risk, and the two may oppose each other's effects on sedation.
What this interaction means in plain words
Phendimetrazine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition and additive cardiovascular effects.
What to do
Monitor heart rate, blood pressure and palpitations, and check an ECG in patients with cardiac risk factors. Avoid in patients with QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Ziprasidone?
MediHelp rates the interaction as moderate. Phendimetrazine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic that can raise heart rate and blood pressure, whereas ziprasidone prolongs the QT interval. Stimulant-induced tachycardia may add to arrhythmic risk, and the two may oppose each other's effects on sedation.
How serious is the interaction between Phendimetrazine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and palpitations, and check an ECG in patients with cardiac risk factors. Avoid in patients with QT prolongation.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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