Drug interactions
Phenelzine + Pimavanserin
Severity: Moderate
Phenelzine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin is a selective serotonin 5-HT2A inverse agonist, and combining it with an irreversible MAO inhibitor could theoretically add to serotonergic and central effects. No well-documented clinical interaction exists, but both drugs are used in patients vulnerable to confusion and orthostasis.
What this interaction means in plain words
Phenelzine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and CNS effects; no established pharmacokinetic interaction.
What to do
Monitor for agitation, tremor, hyperthermia, confusion and blood pressure changes when combining. Stop one agent if signs of serotonin toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Phenelzine with Pimavanserin?
MediHelp rates the interaction as moderate. Phenelzine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin is a selective serotonin 5-HT2A inverse agonist, and combining it with an irreversible MAO inhibitor could theoretically add to serotonergic and central effects. No well-documented clinical interaction exists, but both drugs are used in patients vulnerable to confusion and orthostasis.
How serious is the interaction between Phenelzine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, confusion and blood pressure changes when combining. Stop one agent if signs of serotonin toxicity appear.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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