Drug interactions
Phenelzine + Safinamide
Severity: Contraindicated
Phenelzine and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is an MAO-B inhibitor, and with phenelzine the total MAO inhibition can become nonselective. This raises the risk of hypertensive crisis and serotonin syndrome. Labeling contraindicates concurrent use.
What this interaction means in plain words
Phenelzine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Additive MAO inhibition leads to accumulation of monoamines.
What to do
Avoid; allow at least 14 days after stopping safinamide before starting phenelzine, and the reverse. Use another antidepressant or antiparkinson agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Phenelzine with Safinamide?
MediHelp rates the interaction as contraindicated. Phenelzine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is an MAO-B inhibitor, and with phenelzine the total MAO inhibition can become nonselective. This raises the risk of hypertensive crisis and serotonin syndrome. Labeling contraindicates concurrent use.
How serious is the interaction between Phenelzine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; allow at least 14 days after stopping safinamide before starting phenelzine, and the reverse. Use another antidepressant or antiparkinson agent.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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