Drug interactions
Phenelzine + Salmeterol
Severity: Major
Phenelzine and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol labeling advises extreme caution with MAO inhibitors because vascular effects of the beta-agonist may be potentiated. QT prolongation, tachycardia and hypotension or hypertension may occur.
What this interaction means in plain words
Phenelzine and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phenelzine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
MAO inhibition may potentiate vascular and cardiac effects of beta-agonists.
What to do
Avoid salmeterol during and within 2 weeks of MAOI therapy where possible; otherwise monitor ECG and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Salmeterol?
MediHelp rates the interaction as major. Phenelzine and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Salmeterol labeling advises extreme caution with MAO inhibitors because vascular effects of the beta-agonist may be potentiated. QT prolongation, tachycardia and hypotension or hypertension may occur.
How serious is the interaction between Phenelzine and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid salmeterol during and within 2 weeks of MAOI therapy where possible; otherwise monitor ECG and blood pressure.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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