Drug interactions
Phenindione + Prednisone
Severity: Moderate
Phenindione and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter the response to oral anticoagulants unpredictably, and high doses raise the risk of GI bleeding. INR changes may occur in either direction.
What this interaction means in plain words
Phenindione and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Variable pharmacodynamic effects on coagulation and vascular integrity, plus steroid GI mucosal injury; mechanism not fully defined.
What to do
Check INR more often when starting, changing or stopping prednisone, and adjust the phenindione dose accordingly. Consider gastroprotection with high steroid doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Phenindione with Prednisone?
MediHelp rates the interaction as moderate. Phenindione and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter the response to oral anticoagulants unpredictably, and high doses raise the risk of GI bleeding. INR changes may occur in either direction.
How serious is the interaction between Phenindione and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when starting, changing or stopping prednisone, and adjust the phenindione dose accordingly. Consider gastroprotection with high steroid doses.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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