Drug interactions
Phenobarbital + Procarbazine
Severity: Moderate
Phenobarbital and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine can add to the CNS depressant effects of phenobarbital, causing more sedation. Phenobarbital is also a strong enzyme inducer and may alter procarbazine activation.
What this interaction means in plain words
Phenobarbital and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; enzyme induction by phenobarbital may change procarbazine metabolism.
What to do
Monitor for sedation and for changes in procarbazine toxicity; consider a non-inducing anticonvulsant if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Phenobarbital with Procarbazine?
MediHelp rates the interaction as moderate. Phenobarbital and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine can add to the CNS depressant effects of phenobarbital, causing more sedation. Phenobarbital is also a strong enzyme inducer and may alter procarbazine activation.
How serious is the interaction between Phenobarbital and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for changes in procarbazine toxicity; consider a non-inducing anticonvulsant if clinically appropriate.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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