Drug interactions
Phenobarbital + Tinidazole
Severity: Moderate
Phenobarbital and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an enzyme inducer and may increase the metabolism of tinidazole, lowering its levels. Reduced exposure may lead to treatment failure in infections.
What this interaction means in plain words
Phenobarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenobarbital induces hepatic CYP3A4, increasing tinidazole clearance.
What to do
Monitor clinical response to tinidazole and consider an alternative or adjusted regimen if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Phenobarbital with Tinidazole?
MediHelp rates the interaction as moderate. Phenobarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is an enzyme inducer and may increase the metabolism of tinidazole, lowering its levels. Reduced exposure may lead to treatment failure in infections.
How serious is the interaction between Phenobarbital and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tinidazole and consider an alternative or adjusted regimen if the response is inadequate.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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