Drug interactions
Phenoxybenzamine + Vardenafil
Severity: Major
Phenoxybenzamine and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes long-lasting alpha-blockade, and vardenafil adds vasodilation, so symptomatic hypotension and syncope are possible. The effect may persist because phenoxybenzamine blockade is irreversible.
What this interaction means in plain words
Phenoxybenzamine and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive vasodilation from irreversible alpha-adrenergic blockade and PDE5 inhibition.
What to do
Avoid unless clearly needed; if used, start vardenafil at the lowest dose and monitor supine and standing blood pressure. Advise patients to rise slowly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Phenoxybenzamine with Vardenafil?
MediHelp rates the interaction as major. Phenoxybenzamine and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenoxybenzamine causes long-lasting alpha-blockade, and vardenafil adds vasodilation, so symptomatic hypotension and syncope are possible. The effect may persist because phenoxybenzamine blockade is irreversible.
How serious is the interaction between Phenoxybenzamine and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly needed; if used, start vardenafil at the lowest dose and monitor supine and standing blood pressure. Advise patients to rise slowly.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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