Drug interactions
Phenylephrine po + Procarbazine
Severity: Contraindicated
Phenylephrine po and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is metabolised by MAO in the gut wall and liver, so MAO inhibition by procarbazine can greatly increase its systemic exposure and pressor effect. This can cause hypertensive crisis.
What this interaction means in plain words
Phenylephrine po and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition reduces first-pass metabolism of phenylephrine and potentiates its adrenergic effects.
What to do
Avoid oral phenylephrine decongestants during and for 14 days after procarbazine. Advise patients to check over-the-counter cold products.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Phenylephrine po with Procarbazine?
MediHelp rates the interaction as contraindicated. Phenylephrine po and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral phenylephrine is metabolised by MAO in the gut wall and liver, so MAO inhibition by procarbazine can greatly increase its systemic exposure and pressor effect. This can cause hypertensive crisis.
How serious is the interaction between Phenylephrine po and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral phenylephrine decongestants during and for 14 days after procarbazine. Advise patients to check over-the-counter cold products.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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