Drug interactions
Phenytoin + Tiratricol
Severity: Moderate
Phenytoin and Tiratricol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces hepatic enzymes and can accelerate the clearance of thyroid hormones and analogues. Tiratricol effect may be reduced.
What this interaction means in plain words
Phenytoin and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenytoin belongs to Central Nervous System; Tiratricol belongs to Endocrine.
Why it happens
Hepatic enzyme induction (including glucuronidation) by phenytoin increases tiratricol clearance.
What to do
Monitor T3 and clinical thyroid status, and raise the tiratricol dose if needed. Reassess when phenytoin is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiratricol
- Levothyroxine + Tiratricol Major
- Calcium + Tiratricol Moderate
- Carbamazepine + Tiratricol Moderate
- Carbimazole + Tiratricol Moderate
- Charcoal + Tiratricol Moderate
- Chloroquine + Tiratricol Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Phenytoin with Tiratricol?
MediHelp rates the interaction as moderate. Phenytoin and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces hepatic enzymes and can accelerate the clearance of thyroid hormones and analogues. Tiratricol effect may be reduced.
How serious is the interaction between Phenytoin and Tiratricol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor T3 and clinical thyroid status, and raise the tiratricol dose if needed. Reassess when phenytoin is changed or stopped.
What other medicines interact with Tiratricol?
MediHelp also lists interactions of Tiratricol with, for example, Levothyroxine, Calcium, Carbamazepine. The full list is on the Tiratricol page.
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