Drug interactions
Pimozide + Procarbazine
Severity: Moderate
Pimozide and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitor activity and can cause sedation and hypotension, and it interacts with CNS depressants. Together with pimozide there may be more sedation, orthostatic hypotension, and rarely serotonergic or neuroleptic malignant-type reactions.
What this interaction means in plain words
Pimozide and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive CNS depression plus weak MAO inhibition that may enhance monoaminergic effects.
What to do
Monitor for sedation, blood pressure changes, hyperthermia and rigidity. Reduce doses if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pimozide and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Pimozide with Procarbazine?
MediHelp rates the interaction as moderate. Pimozide and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitor activity and can cause sedation and hypotension, and it interacts with CNS depressants. Together with pimozide there may be more sedation, orthostatic hypotension, and rarely serotonergic or neuroleptic malignant-type reactions.
How serious is the interaction between Pimozide and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, blood pressure changes, hyperthermia and rigidity. Reduce doses if excess sedation occurs.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
