Drug interactions
Pimozide + Voclosporin
Severity: Major
Pimozide and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic exposures, and pimozide has marked QT-prolonging effects. Combined use increases the risk of serious ventricular arrhythmias, and voclosporin is also a CYP3A4 inhibitor that may increase pimozide levels.
What this interaction means in plain words
Pimozide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT prolongation, plus weak CYP3A4 inhibition by voclosporin that may raise pimozide levels.
What to do
Avoid coadministration where possible. If necessary, obtain a baseline and follow-up ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Pimozide with Voclosporin?
MediHelp rates the interaction as major. Pimozide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin can prolong the QT interval at supratherapeutic exposures, and pimozide has marked QT-prolonging effects. Combined use increases the risk of serious ventricular arrhythmias, and voclosporin is also a CYP3A4 inhibitor that may increase pimozide levels.
How serious is the interaction between Pimozide and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If necessary, obtain a baseline and follow-up ECG and keep potassium and magnesium normal.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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