Drug interactions
Pimozide + Voxelotor
Severity: Major
Pimozide and Voxelotor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to sensitive substrates. Pimozide is metabolized partly by CYP3A4 and has a narrow therapeutic index, so higher levels can cause QT prolongation and ventricular arrhythmias.
What this interaction means in plain words
Pimozide and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing the metabolic clearance of pimozide.
What to do
Avoid coadministration if possible. If it cannot be avoided, reduce the pimozide dose and monitor ECG for QTc prolongation and for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Pimozide with Voxelotor?
MediHelp rates the interaction as major. Pimozide and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voxelotor inhibits CYP3A4 and can raise exposure to sensitive substrates. Pimozide is metabolized partly by CYP3A4 and has a narrow therapeutic index, so higher levels can cause QT prolongation and ventricular arrhythmias.
How serious is the interaction between Pimozide and Voxelotor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible. If it cannot be avoided, reduce the pimozide dose and monitor ECG for QTc prolongation and for adverse effects.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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