Drug interactions
Pindolol + Prilocaine
Severity: Minor
Pindolol and Prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of prilocaine may cause hypotension and conduction effects that add to the effects of pindolol. The risk is small with standard dental or regional doses.
What this interaction means in plain words
Pindolol and Prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive and negative chronotropic effects from beta blockade and local anesthetic sodium channel blockade.
What to do
Use the lowest effective prilocaine dose and monitor heart rate and blood pressure in patients receiving large doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prilocaine
- Bupivacaine implant + Prilocaine Major
- Nitric oxide + Prilocaine Major
- Phenazopyridine + Prilocaine Major
- Prilocaine + Propranolol Moderate
- Prilocaine + Timolol Moderate
- Hyaluronidase + Prilocaine Minor
Frequently asked questions
Can I take Pindolol with Prilocaine?
MediHelp rates the interaction as minor. Pindolol and Prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of prilocaine may cause hypotension and conduction effects that add to the effects of pindolol. The risk is small with standard dental or regional doses.
How serious is the interaction between Pindolol and Prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prilocaine dose and monitor heart rate and blood pressure in patients receiving large doses.
What other medicines interact with Prilocaine?
MediHelp also lists interactions of Prilocaine with, for example, Bupivacaine implant, Nitric oxide, Phenazopyridine. The full list is on the Prilocaine page.
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