Drug interactions
Hyaluronidase + Prilocaine
Severity: Minor
Hyaluronidase and Prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyaluronidase spreads injected anesthetic through tissue, which speeds onset but shortens duration of the block. It also raises systemic absorption of prilocaine, which may increase the chance of systemic effects such as methemoglobinemia.
What this interaction means in plain words
Hyaluronidase and Prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyaluronidase belongs to Miscellaneous; Prilocaine belongs to Central Nervous System.
Why it happens
Hyaluronidase degrades tissue hyaluronan, enhancing dispersion and systemic absorption of prilocaine.
What to do
Anticipate a shorter duration of anesthesia and keep prilocaine within maximum recommended doses; monitor for systemic toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hyaluronidase and Prilocaine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prilocaine
- Bupivacaine implant + Prilocaine Major
- Nitric oxide + Prilocaine Major
- Phenazopyridine + Prilocaine Major
- Prilocaine + Propranolol Moderate
- Prilocaine + Timolol Moderate
- Nadolol + Prilocaine Minor
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Hyaluronidase with Prilocaine?
MediHelp rates the interaction as minor. Hyaluronidase and Prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hyaluronidase spreads injected anesthetic through tissue, which speeds onset but shortens duration of the block. It also raises systemic absorption of prilocaine, which may increase the chance of systemic effects such as methemoglobinemia.
How serious is the interaction between Hyaluronidase and Prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anticipate a shorter duration of anesthesia and keep prilocaine within maximum recommended doses; monitor for systemic toxicity.
What other medicines interact with Prilocaine?
MediHelp also lists interactions of Prilocaine with, for example, Bupivacaine implant, Nitric oxide, Phenazopyridine. The full list is on the Prilocaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
