Drug interactions
Prilocaine + Propranolol
Severity: Moderate
Prilocaine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prilocaine can cause cardiovascular depression when absorbed systemically, and propranolol may add to hypotension and bradycardia. Systemic exposure is greater with large-dose infiltration or regional blocks, and epinephrine-containing preparations may produce hypertension with reflex bradycardia in patients on nonselective beta-blockers.
What this interaction means in plain words
Prilocaine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prilocaine belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Additive cardiac depressant effects, with unopposed alpha effects of any co-administered epinephrine during nonselective beta-blockade.
What to do
Monitor blood pressure and heart rate when larger anesthetic doses are used, and limit the dose of epinephrine-containing prilocaine. Routine small dental doses generally need no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Prilocaine
- Bupivacaine implant + Prilocaine Major
- Nitric oxide + Prilocaine Major
- Phenazopyridine + Prilocaine Major
- Prilocaine + Timolol Moderate
- Hyaluronidase + Prilocaine Minor
- Nadolol + Prilocaine Minor
Frequently asked questions
Can I take Prilocaine with Propranolol?
MediHelp rates the interaction as moderate. Prilocaine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prilocaine can cause cardiovascular depression when absorbed systemically, and propranolol may add to hypotension and bradycardia. Systemic exposure is greater with large-dose infiltration or regional blocks, and epinephrine-containing preparations may produce hypertension with reflex bradycardia in patients on nonselective beta-blockers.
How serious is the interaction between Prilocaine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when larger anesthetic doses are used, and limit the dose of epinephrine-containing prilocaine. Routine small dental doses generally need no change.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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