Drug interactions
Pindolol + Tolazamide
Severity: Moderate
Pindolol and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations, and can prolong recovery from lows. Nonselective agents may also impair glucose recovery and slightly alter glycemic control.
What this interaction means in plain words
Pindolol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade suppresses hypoglycemia symptoms and counter-regulatory glucose mobilization.
What to do
Monitor blood glucose more often and educate the patient that sweating may remain the main warning sign. Prefer a cardioselective beta-blocker if one is appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Pindolol with Tolazamide?
MediHelp rates the interaction as moderate. Pindolol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations, and can prolong recovery from lows. Nonselective agents may also impair glucose recovery and slightly alter glycemic control.
How serious is the interaction between Pindolol and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and educate the patient that sweating may remain the main warning sign. Prefer a cardioselective beta-blocker if one is appropriate.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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