Drug interactions
Pindolol + Umeclidinium-vilanterol
Severity: Major
Pindolol and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol is a non-selective beta-blocker that can block the bronchodilating action of vilanterol. In patients with COPD it may also provoke bronchospasm and reduce the benefit of the inhaler.
What this interaction means in plain words
Pindolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a non-selective beta-blocker opposing the beta-2 agonist vilanterol.
What to do
Avoid non-selective beta-blockers such as pindolol in patients with COPD on this inhaler; if a beta-blocker is essential, choose a cardioselective agent at the lowest effective dose. Monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Pindolol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Pindolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pindolol is a non-selective beta-blocker that can block the bronchodilating action of vilanterol. In patients with COPD it may also provoke bronchospasm and reduce the benefit of the inhaler.
How serious is the interaction between Pindolol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers such as pindolol in patients with COPD on this inhaler; if a beta-blocker is essential, choose a cardioselective agent at the lowest effective dose. Monitor respiratory symptoms and lung function.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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