Drug interactions
Pioglitazone + Somapacitan
Severity: Moderate
Pioglitazone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and can raise blood glucose. This may offset the glucose-lowering effect of pioglitazone, especially at higher growth hormone doses.
What this interaction means in plain words
Pioglitazone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pioglitazone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance, pharmacodynamically opposing the insulin-sensitizing action of pioglitazone.
What to do
Monitor blood glucose and HbA1c after starting or changing somapacitan. Increase the pioglitazone dose or the antidiabetic regimen if glycemic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Pioglitazone with Somapacitan?
MediHelp rates the interaction as moderate. Pioglitazone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and can raise blood glucose. This may offset the glucose-lowering effect of pioglitazone, especially at higher growth hormone doses.
How serious is the interaction between Pioglitazone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing somapacitan. Increase the pioglitazone dose or the antidiabetic regimen if glycemic control worsens.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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