Drug interactions
Pioglitazone + Somatrogon
Severity: Moderate
Pioglitazone and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogues such as somatrogon decrease insulin sensitivity and can raise blood glucose. This may reduce the effectiveness of pioglitazone in patients with diabetes.
What this interaction means in plain words
Pioglitazone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pioglitazone belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone induced insulin resistance antagonizes the insulin-sensitizing effect of pioglitazone.
What to do
Monitor glucose and HbA1c when somatrogon is started or the dose changed. Adjust the antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pioglitazone and Somatrogon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pioglitazone
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Pioglitazone with Somatrogon?
MediHelp rates the interaction as moderate. Pioglitazone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogues such as somatrogon decrease insulin sensitivity and can raise blood glucose. This may reduce the effectiveness of pioglitazone in patients with diabetes.
How serious is the interaction between Pioglitazone and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when somatrogon is started or the dose changed. Adjust the antidiabetic therapy as required.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
