Drug interactions
Pirbuterol + Procarbazine
Severity: Moderate
Pirbuterol and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity, and sympathomimetics may produce exaggerated adrenergic effects with MAO inhibitors. This could cause hypertension, tachycardia or palpitations, although inhaled pirbuterol has low systemic exposure.
What this interaction means in plain words
Pirbuterol and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition by procarbazine may potentiate the sympathomimetic effects of pirbuterol.
What to do
Monitor blood pressure and heart rate when starting pirbuterol in patients on procarbazine. Use the lowest effective dose and avoid frequent use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Pirbuterol with Procarbazine?
MediHelp rates the interaction as moderate. Pirbuterol and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibiting activity, and sympathomimetics may produce exaggerated adrenergic effects with MAO inhibitors. This could cause hypertension, tachycardia or palpitations, although inhaled pirbuterol has low systemic exposure.
How serious is the interaction between Pirbuterol and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting pirbuterol in patients on procarbazine. Use the lowest effective dose and avoid frequent use.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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