Drug interactions
Pirbuterol + Ziprasidone
Severity: Moderate
Pirbuterol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval or provoke tachyarrhythmias, and beta-agonist related hypokalemia can further raise the risk of torsades de pointes. The risk is greatest with high doses, electrolyte disturbance or underlying cardiac disease.
What this interaction means in plain words
Pirbuterol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia increasing arrhythmic susceptibility.
What to do
Correct potassium and magnesium before and during therapy and consider ECG monitoring in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Pirbuterol with Ziprasidone?
MediHelp rates the interaction as moderate. Pirbuterol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval or provoke tachyarrhythmias, and beta-agonist related hypokalemia can further raise the risk of torsades de pointes. The risk is greatest with high doses, electrolyte disturbance or underlying cardiac disease.
How serious is the interaction between Pirbuterol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy and consider ECG monitoring in patients with cardiac risk factors.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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