Drug interactions
Pirfenidone + Somatrogon
Severity: Minor
Pirfenidone and Somatrogon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity, including CYP1A2. This could lower pirfenidone exposure and weaken its effect, though the clinical significance is uncertain.
What this interaction means in plain words
Pirfenidone and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pirfenidone belongs to Miscellaneous; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone may induce CYP1A2, increasing pirfenidone clearance.
What to do
No routine adjustment is needed; monitor clinical response and lung function when somatrogon is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pirfenidone
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Pirfenidone with Somatrogon?
MediHelp rates the interaction as minor. Pirfenidone and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450 activity, including CYP1A2. This could lower pirfenidone exposure and weaken its effect, though the clinical significance is uncertain.
How serious is the interaction between Pirfenidone and Somatrogon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response and lung function when somatrogon is started or stopped.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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