Drug interactions
Pirtobrutinib + Quinine
Severity: Moderate
Pirtobrutinib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib is a weak CYP3A4 inhibitor and may modestly raise quinine concentrations. This may increase cinchonism and QT risk.
What this interaction means in plain words
Pirtobrutinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirtobrutinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Pirtobrutinib inhibits CYP3A4, reducing quinine clearance.
What to do
Monitor for quinine adverse effects and QTc if risk factors are present. Reduce the quinine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Pirtobrutinib with Quinine?
MediHelp rates the interaction as moderate. Pirtobrutinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib is a weak CYP3A4 inhibitor and may modestly raise quinine concentrations. This may increase cinchonism and QT risk.
How serious is the interaction between Pirtobrutinib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine adverse effects and QTc if risk factors are present. Reduce the quinine dose if toxicity develops.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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