Drug interactions
Pitavastatin + Regorafenib
Severity: Minor
Pitavastatin and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP, a transporter involved in pitavastatin disposition. Pitavastatin exposure could increase, raising the potential for muscle adverse effects.
What this interaction means in plain words
Pitavastatin and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pitavastatin belongs to Cardiovascular; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibits BCRP (ABCG2), potentially reducing pitavastatin efflux.
What to do
Ask patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Pitavastatin with Regorafenib?
MediHelp rates the interaction as minor. Pitavastatin and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit BCRP, a transporter involved in pitavastatin disposition. Pitavastatin exposure could increase, raising the potential for muscle adverse effects.
How serious is the interaction between Pitavastatin and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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