Drug interactions
Pitolisant + Sorafenib
Severity: Moderate
Pitolisant and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval and labeling advises avoiding it with other QT-prolonging drugs. Sorafenib adds to this risk, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Pitolisant and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitolisant belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct electrolytes before combining. Monitor the QTc periodically, or choose another wake-promoting agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Sorafenib?
MediHelp rates the interaction as moderate. Pitolisant and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can prolong the QT interval and labeling advises avoiding it with other QT-prolonging drugs. Sorafenib adds to this risk, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Pitolisant and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before combining. Monitor the QTc periodically, or choose another wake-promoting agent.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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