Drug interactions
Pneumococcal vaccine heptavalent + Procarbazine
Severity: Moderate
Pneumococcal vaccine heptavalent and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine can blunt the response to pneumococcal conjugate vaccine. Patients receiving chemotherapy are already at higher risk of pneumococcal infection, so reduced immunogenicity is relevant.
What this interaction means in plain words
Pneumococcal vaccine heptavalent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression blunts the humoral response to vaccine antigens.
What to do
Vaccinate at least 2 weeks before procarbazine when possible; consider revaccination about 3 months after therapy if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine heptavalent with Procarbazine?
MediHelp rates the interaction as moderate. Pneumococcal vaccine heptavalent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine can blunt the response to pneumococcal conjugate vaccine. Patients receiving chemotherapy are already at higher risk of pneumococcal infection, so reduced immunogenicity is relevant.
How serious is the interaction between Pneumococcal vaccine heptavalent and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before procarbazine when possible; consider revaccination about 3 months after therapy if given during treatment.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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