Drug interactions
Pneumococcal vaccine polyvalent + Ustekinumab
Severity: Minor
Pneumococcal vaccine polyvalent and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may reduce the antibody response to inactivated pneumococcal vaccine. Protection against pneumococcal disease may be incomplete.
What this interaction means in plain words
Pneumococcal vaccine polyvalent and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunomodulation through IL-12/23 inhibition may reduce vaccine immune response.
What to do
Give pneumococcal vaccination before starting ustekinumab when feasible. Do not withhold the vaccine in treated patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Pneumococcal vaccine polyvalent with Ustekinumab?
MediHelp rates the interaction as minor. Pneumococcal vaccine polyvalent and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may reduce the antibody response to inactivated pneumococcal vaccine. Protection against pneumococcal disease may be incomplete.
How serious is the interaction between Pneumococcal vaccine polyvalent and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pneumococcal vaccination before starting ustekinumab when feasible. Do not withhold the vaccine in treated patients.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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