Drug interactions
Poliovirus vaccine inactivated + Ustekinumab
Severity: Minor
Poliovirus vaccine inactivated and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may modestly reduce the immune response to inactivated vaccines. Inactivated polio vaccine is safe to give but protection could be suboptimal.
What this interaction means in plain words
Poliovirus vaccine inactivated and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-12/23 inhibition may modestly dampen vaccine-induced immune responses.
What to do
Complete the vaccination series before starting ustekinumab if possible. Otherwise vaccinate as scheduled and consider checking immunity in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Poliovirus vaccine inactivated with Ustekinumab?
MediHelp rates the interaction as minor. Poliovirus vaccine inactivated and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may modestly reduce the immune response to inactivated vaccines. Inactivated polio vaccine is safe to give but protection could be suboptimal.
How serious is the interaction between Poliovirus vaccine inactivated and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the vaccination series before starting ustekinumab if possible. Otherwise vaccinate as scheduled and consider checking immunity in high-risk patients.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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