Drug interactions
Ponatinib + Quinidine
Severity: Moderate
Ponatinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may raise ponatinib concentrations through CYP3A4 inhibition. Ponatinib has serious vascular, cardiac and hepatic toxicity, so higher exposure is a concern.
What this interaction means in plain words
Ponatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4-mediated metabolism of ponatinib.
What to do
Monitor for ponatinib toxicity, including hypertension and cardiac events. Consider a ponatinib dose reduction if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Quinidine?
MediHelp rates the interaction as moderate. Ponatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may raise ponatinib concentrations through CYP3A4 inhibition. Ponatinib has serious vascular, cardiac and hepatic toxicity, so higher exposure is a concern.
How serious is the interaction between Ponatinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ponatinib toxicity, including hypertension and cardiac events. Consider a ponatinib dose reduction if adverse effects occur.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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