Drug interactions
Ponatinib + Simvastatin
Severity: Moderate
Ponatinib and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-gp and BCRP and may increase simvastatin exposure. This could heighten the risk of statin-related myopathy.
What this interaction means in plain words
Ponatinib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Ponatinib inhibits efflux transporters (P-gp, BCRP), increasing simvastatin absorption and exposure.
What to do
Monitor for muscle pain and weakness and use the lowest effective simvastatin dose. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Simvastatin?
MediHelp rates the interaction as moderate. Ponatinib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-gp and BCRP and may increase simvastatin exposure. This could heighten the risk of statin-related myopathy.
How serious is the interaction between Ponatinib and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain and weakness and use the lowest effective simvastatin dose. Check CK if symptoms occur.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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