Drug interactions
Ponesimod + Trastuzumab
Severity: Moderate
Ponesimod and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod lowers circulating lymphocyte counts, and trastuzumab may add to infection risk in patients also receiving cytotoxic therapy. Concurrent use could increase susceptibility to infections, and the lymphocyte effect of ponesimod persists for some time after stopping.
What this interaction means in plain words
Ponesimod and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponesimod belongs to Central Nervous System; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppression from sphingosine-1-phosphate receptor modulation (lymphocyte sequestration) plus the hematologic effects of trastuzumab-based therapy.
What to do
Monitor for infections and check lymphocyte and neutrophil counts. Consider the persistent effect of ponesimod when planning sequential therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Ponesimod with Trastuzumab?
MediHelp rates the interaction as moderate. Ponesimod and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponesimod lowers circulating lymphocyte counts, and trastuzumab may add to infection risk in patients also receiving cytotoxic therapy. Concurrent use could increase susceptibility to infections, and the lymphocyte effect of ponesimod persists for some time after stopping.
How serious is the interaction between Ponesimod and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and check lymphocyte and neutrophil counts. Consider the persistent effect of ponesimod when planning sequential therapy.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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