Drug interactions
Potassium citrate-citric acid + Voclosporin
Severity: Moderate
Potassium citrate-citric acid and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia. Potassium supplementation adds to this risk.
What this interaction means in plain words
Potassium citrate-citric acid and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Potassium citrate-citric acid belongs to Gastrointestinal Tract; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibition reduces renal potassium excretion, which adds to the exogenous potassium.
What to do
Monitor serum potassium regularly and avoid unnecessary potassium supplements. Adjust or stop potassium if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Potassium citrate-citric acid
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Potassium citrate-citric acid with Voclosporin?
MediHelp rates the interaction as moderate. Potassium citrate-citric acid and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia. Potassium supplementation adds to this risk.
How serious is the interaction between Potassium citrate-citric acid and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and avoid unnecessary potassium supplements. Adjust or stop potassium if levels rise.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
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