Drug interactions
Pralatrexate + Sulfamethoxazole
Severity: Moderate
Pralatrexate and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole, usually given with trimethoprim, may reduce renal elimination of pralatrexate. Trimethoprim is also an antifolate, which may add to mucositis and myelosuppression.
What this interaction means in plain words
Pralatrexate and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and additive antifolate effects reduce pralatrexate clearance and increase toxicity.
What to do
Monitor blood counts, mucositis and renal function when co-prescribed. Pralatrexate labeling advises monitoring with drugs such as trimethoprim/sulfamethoxazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Pralatrexate with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Pralatrexate and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole, usually given with trimethoprim, may reduce renal elimination of pralatrexate. Trimethoprim is also an antifolate, which may add to mucositis and myelosuppression.
How serious is the interaction between Pralatrexate and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, mucositis and renal function when co-prescribed. Pralatrexate labeling advises monitoring with drugs such as trimethoprim/sulfamethoxazole.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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