Drug interactions
Pramipexole + Tenofovir df
Severity: Moderate
Pramipexole and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pramipexole is eliminated largely unchanged by renal tubular secretion, and tenofovir is also actively secreted by the kidney. Competition for this pathway may raise pramipexole concentrations and increase dopaminergic adverse effects such as somnolence, nausea, dizziness and hallucinations. Tenofovir-related renal impairment could further reduce pramipexole clearance.
What this interaction means in plain words
Pramipexole and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion via organic cation and anion transporters reduces pramipexole clearance.
What to do
Monitor for pramipexole adverse effects and renal function, and lower the pramipexole dose if effects emerge. Adjust dosing according to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Pramipexole with Tenofovir df?
MediHelp rates the interaction as moderate. Pramipexole and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pramipexole is eliminated largely unchanged by renal tubular secretion, and tenofovir is also actively secreted by the kidney. Competition for this pathway may raise pramipexole concentrations and increase dopaminergic adverse effects such as somnolence, nausea, dizziness and hallucinations. Tenofovir-related renal impairment could further reduce pramipexole clearance.
How serious is the interaction between Pramipexole and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pramipexole adverse effects and renal function, and lower the pramipexole dose if effects emerge. Adjust dosing according to creatinine clearance.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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