Drug interactions
Prazosin + Sulindac
Severity: Minor
Prazosin and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can partly offset the blood pressure lowering effect of antihypertensives through fluid retention. The effect with prazosin is probably small but may be noticeable in some patients.
What this interaction means in plain words
Prazosin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prazosin belongs to Genitourinary; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins promotes sodium and water retention, opposing alpha-blocker vasodilation.
What to do
Check blood pressure after sulindac is started or stopped and adjust prazosin if control is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Sulindac?
MediHelp rates the interaction as minor. Prazosin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can partly offset the blood pressure lowering effect of antihypertensives through fluid retention. The effect with prazosin is probably small but may be noticeable in some patients.
How serious is the interaction between Prazosin and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure after sulindac is started or stopped and adjust prazosin if control is reduced.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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